Biochem/physiol Actions

Primary Target5-HT_5A

General description

A selective, brain penetrant, 5-HT_5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT_5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT_1A/B/D, 5-HT_2A/C and 5-5-HT₇).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ferenc, K. et al. 2012. Behav. Pharmacol.23, 397.Thomas, D. R. et al. 2006. Neuropharmacol.51, 566. Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett.15, 4014.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)